【佳學(xué)基因檢測】腫瘤致病基因突變發(fā)生的時間和地點(diǎn)確定了！

正確定位體細(xì)胞驅(qū)動基因突變的時間（之所以稱為體細(xì)胞驅(qū)動基因突變是因?yàn)樗鼈?ldquo;驅(qū)動”了癌癥的發(fā)生和發(fā)展）有助于早期發(fā)現(xiàn)和干預(yù)策略。在《自然》雜志上，Williams等人重建了12例成人型骨髓增生性腫瘤患者的造血系統(tǒng)發(fā)育并追蹤克隆進(jìn)化動力學(xué)，揭示了這些癌癥的初始驅(qū)動突變通常發(fā)生在兒童時期，包括子宮內(nèi)。
 

Pinpointing the timing of somatic driver mutations, so called because they ‘drive’ cancer initiation and progression, could help with early detection and intervention strategies. In Nature, Williams et al. reconstruct haematopoietic phylogenies and track clonal evolutionary dynamics in 12 patients with adult-onset myeloproliferative neoplasms, revealing that initial driver mutations of these cancers often occur during childhood, including in utero.