【佳學(xué)基因檢測】卵巢癌正確治療：馮煒煒教授
遺傳病、罕見病基因檢測導(dǎo)讀：
上海交通大學(xué)附屬瑞金醫(yī)院馮煒煒教授因致力于研究子宮體腫瘤的正確診療，卵巢癌反復(fù)、轉(zhuǎn)移的表觀遺傳調(diào)節(jié)機(jī)制，而成為國際知名的卵巢癌、子宮體腫瘤正確治療專家。馮煒煒教授簡介：
馮煒煒教授馮煒煒，上海醫(yī)科大學(xué)醫(yī)學(xué)博士和挪威Bergen大學(xué)博士，美國M.D. Anderson 癌癥中心博士后，教授，博士生導(dǎo)師，現(xiàn)任上海交通大學(xué)醫(yī)學(xué)院附屬瑞金醫(yī)院婦產(chǎn)科主任，住院醫(yī)師規(guī)范化培訓(xùn)瑞金醫(yī)院婦產(chǎn)科專業(yè)基地主任，兼任中國醫(yī)師協(xié)會(huì)婦產(chǎn)科醫(yī)師分會(huì)婦科腫瘤專業(yè)委員會(huì)委員，上海市醫(yī)師協(xié)會(huì)婦科腫瘤學(xué)醫(yī)師分會(huì)委員會(huì)委員，世界華人婦產(chǎn)科醫(yī)師協(xié)會(huì)NOTES微創(chuàng)醫(yī)學(xué)專業(yè)委員會(huì)，中國醫(yī)師協(xié)會(huì)整合醫(yī)學(xué)分會(huì)上海盆底專業(yè)委員會(huì)副主任委員，中國婦幼保健協(xié)會(huì)婦科智能（AI）醫(yī)學(xué)專業(yè)委員會(huì)委員，上海市婦科質(zhì)控專家委員會(huì)委員，第五屆上海市醫(yī)學(xué)會(huì)醫(yī)療事故技術(shù)鑒定專家，上海市藥學(xué)會(huì)第十一屆藥物治療專業(yè)委員會(huì)委員，《現(xiàn)代婦產(chǎn)科進(jìn)展》第五屆編委會(huì)編委等。從事臨床工作25年，對婦科常見和疑難病有豐富診療經(jīng)驗(yàn)，主攻方向?yàn)閶D科腫瘤的綜合診治。擅長腹腔鏡手術(shù)和機(jī)器人手術(shù)，熟練掌握廣泛子宮切除、腹主動(dòng)脈旁淋巴清掃等婦科高難度手術(shù)，四級手術(shù)量200例/年以上。科研方面，擅于從臨床治療實(shí)踐中凝練科學(xué)問題，目前主要研究方向是子宮體腫瘤的正確診療，卵巢癌反復(fù)、轉(zhuǎn)移的表觀遺傳調(diào)節(jié)機(jī)制。目前共獲得國家自然科學(xué)基金委和上海市科委等項(xiàng)目資助10項(xiàng)，發(fā)表論文70余篇，先進(jìn)作者或通訊作者發(fā)表SCI 收錄論著35篇，論文被選中國際會(huì)議（2010年IGCS）口頭發(fā)言1次。
院馮煒煒教授.jpg)
馮煒煒教授致力于腫瘤正確醫(yī)學(xué)人才的培養(yǎng)與先進(jìn)治療技術(shù)的推廣
2018年4月起 中國醫(yī)師協(xié)會(huì)整合醫(yī)學(xué)分會(huì) 上海盆底專業(yè)委員會(huì)副主任委員
2015.12-2019.12 上海市藥學(xué)會(huì)第十一屆藥物治療專業(yè)委員會(huì)委員
2016.4- 上海市醫(yī)學(xué)會(huì)婦科腫瘤?？品謺?huì)第二屆委員會(huì)子宮內(nèi)膜癌學(xué)組副組長
2012-2016： 上海市醫(yī)學(xué)會(huì)婦科腫瘤?？品謺?huì)先進(jìn)屆委員會(huì)青年委員
2018.6 上海醫(yī)師協(xié)會(huì)婦科腫瘤分會(huì)先進(jìn)屆委員會(huì)委員
2010- 國際婦科腫瘤協(xié)會(huì)（IGCS）會(huì)員
馮煒煒教授所承擔(dān)的國家及各級研究課題
17411950504 高齡產(chǎn)婦瘢痕子宮及相關(guān)胎盤疾病的早期預(yù)測及標(biāo)準(zhǔn)化干預(yù)模式研究 上海市科委 2017-10~2020-09 45萬元 子課題負(fù)責(zé)人
20172003 利用循環(huán)腫瘤DNA監(jiān)測高危子宮內(nèi)膜癌和卵巢癌反復(fù)轉(zhuǎn)移的探索性研究 交大醫(yī)學(xué)院高原高峰人才計(jì)劃 2017-07~2020-06 100萬元 課題負(fù)責(zé)人
16411953500 子宮內(nèi)膜癌臨床數(shù)據(jù)倉庫建設(shè)和正確診療模型研究 上海市科學(xué)技術(shù)委員會(huì)生藥處重點(diǎn)項(xiàng)目 2016-07~2019-09 50萬元 課題負(fù)責(zé)人
81572836 組蛋白甲基化酶SMYD3在調(diào)節(jié)卵巢癌種植轉(zhuǎn)移中的作用 國家自然科學(xué)基金面上項(xiàng)目 2016-01~2019-12 68.4萬元 課題負(fù)責(zé)人
馮煒煒教授在國際婦科腫瘤正確治療領(lǐng)域的突出成就
Zhu Menhan, Jia Nan, Huang Feifei, Liu Xiaoxia, Zhao Yuqing, Tao Xiang, Jiang Wei, Li Qin, Feng Weiwei. （通訊作者） Whether intermediate-risk stage 1A, grade 1/2, endometrioid endometrial cancer patients with lesions larger than 2?cm warrant lymph node dissection? BMC Cancer. 2017 17(1):696
Jia Nan, Chen Y, Tao Xiang, Ou E, Lu Xin, Feng Weiwei. （通訊作者） A gestational choriocarcinoma of the ovary diagnosed by DNA polymorphic analysis: a case report and systematic review of the literature. J Ovarian Res. 2017 10(1):46.
Jiang Wei, Chen Jun, Tao Xiang, Huang Feifei, Zhu Menghan, Wang Chao, Feng Weiwei （通訊作者） Possible Risk Factors of Pulmonary Metastases in Patients With International Federation of Gynecology and Obstetrics Stage I Endometrioid-Type Endometrial Cancer. Int J Gynecol Cancer 2017 27(6):1206-1215
Jia Nan, Wang Jieyu, Li Qing, Tao Xiang, Chang Kaikai, Hua Keqin, Yu Yinhua, Wong Kwong-Kwok, Feng Weiwei （通訊作者） DNA methylation promotes paired box 2 expression via myeloid zinc finger 1 in endometrial cancer Oncotarget 2016 7(51):84785-84797
Wang Jieyu, Jia Nan, Li Qing, Wang Chao, Tao Xiang, Hua Keqin, Feng Weiwei （通訊作者） Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma. Oncology Letters 2016 12(4):2860-2867
Chao Wang, Weiwei Feng （共同先進(jìn)作者）, Chuyao Zhang. The Expression and Function of NUMB in Endometrial Cancer and the Interaction with HDM2 and P53 Journal of Cancer. 2015 6(10): 1030-1040
Menghan Zhu, Yuan He, Jan PA Baak, Xianrong Zhou, Yuqing Qu, Long Sui, Weiwei Feng and Qing Wang Factors that influence persistence or recurrence of high-grade squamous intraepithelial lesion with positive margins after the loop electrosurgical excision procedure: a retrospective study BMC Cancer 2015 20;15:744-751
Zhang Chuyao, Hu Weiguo, Jia Nan, Li Qing, Hua Keqin, Tao Xiang, Wang Li, Feng Weiwei （通訊作者） Uterine Carcinosarcoma and High-Risk Endometrial Carcinomas: A Clinicopathological Comparison. Int J Gynecol Cancer. 2015 25(4):629-636.
Jia Nan, Li Qing, Tao Xiang, Wang Jieyu, Hua Keqin, Feng Weiwei （通訊作者） Enhancer of zeste homolog 2 is involved in the proliferation of endometrial carcinoma. Oncology Letters 2014 8(5):2049-2054.
Qing Li, Xiang Tao, Guofu Zhang, Weiwei Feng （通訊作者） Leukemoid reaction in cervical cancer: a case report and review of the literature BMC Cancer. 2014 14:670 -677
Lu Zhiying, Zhang Ying, Yan Xaohui, Chen Yisong, Tao Xiang, Wang Jiajia, Jia Nan, Lyu Tianjiao, Wang Junyan, Ding Jingxin, Feng Weiwei （通訊作者）, Hua Keqin Estrogen stimulates the invasion of ovarian cancer cells via activation of the PI3K/AKT pathway and regulation of its downstream targets E cadherin and α actinin 4. Mol Med Rep. 2014 10(5):2433-40
Xiaohui Yan, Tianjiao Lyu., Nan Jia, Yinhua Yu, Keqin Hua, Weiwei Feng （通訊作者） Huaier Aqueous Extract Inhibits Ovarian Cancer Cell Motility via the AKT/GSK3b/b-Catenin Pathway. Plos One. 2013 8(5): e63731
Lyu Tianjiao, Jia Nan, Wang Jieyu, Yan Xiaohui, Yu Yinhua, Lu Zhen, Bast RC Jr, Hua Keqin, Feng Weiwei （通訊作者） Expression and epigenetic regulation of angiogenesis-related factors during dormancy and recurrent growth of ovarian carcinoma. Epigenetics. 2013 17;8(12):
Feng Weiwei*, Malpica Anais, Skaland I, Gudlaugsson E, Robboy SJ, Dalen I, Hua K, Zhou Xianrong, Baak JP Can proliferation biomarkers reliably predict recurrence in world health organization 2003 defined endometrial stromal sarcoma, low grade? PLoS One. 2013 8(10):e75899
Feng Weiwei, Hua Keqin, Anais Malpica, Zhou Xianrong, Baak Jan.P. Stages I-II WHO2003 Defined Endometrial Stromal Sarcoma, Low Grade: How Much Primary Therapy Is Needed and How Little Is Enough? International Journal of Gynecological Cancer 2013 23(3):488-93
Feng Weiwei （通訊作者）, Hua Keqin, Gudlaugsson Einar, Yu Yinhua, Zhou Xianrong, Baak P.Jan. Prognostic indicators in WHO 2003 low-grade endometrial stromal sarcoma. Histopathology. 2013 62(5):675-87
Feng Weiwei （通訊作者）, Malpica Anais, Yinhua Yu, Janssen Emiel, Gudlaugsson Einar, Zhou Xianrong, Baak Jan P Diagnostic and prognostic morphometric features in WHO2003 invasive endometrial stromal tumours. . Histopathology. 2013 62(5):688-694
Feng Weiwei* （通訊作者）, Malpica Anias, Robboy Stanley J, Gudlaugsson Einar, Hua Keqin, Zhou Xianrong, Baak Jan P Prognostic Value of the Diagnostic Criteria Distinguishing Endometrial Stromal Sarcoma, Low Grade From Undifferentiated Endometrial Sarcoma, 2 Entities Within the Invasive Endometrial Stromal Neoplasia Family Int J Gynecol Pathol. 2013 32(3):299-306
Chuyao Zhang, Chao Wang, and Weiwei Feng*. （通訊作者） Clinicopathological Risk Factors for Pelvic Lymph Node Metastasis in Clinical Early-Stage Endometrioid Endometrial Adenocarcinoma. International Journal of Gynecological Cancer. 2012 22, 1373-1377.
(責(zé)任編輯：佳學(xué)基因)
