【佳學(xué)基因檢測(cè)】外泌體微小RNA介導(dǎo)的腫瘤微環(huán)境中胰腺癌細(xì)胞與癌癥相關(guān)成纖維細(xì)胞之間的影響

腫瘤基因檢測(cè)哪家機(jī)構(gòu)賊好導(dǎo)讀

根據(jù)影響腫瘤風(fēng)險(xiǎn)及靶向藥物治療效果的因素高峰論壇，《Int J Mol Sci》在. 2022 Aug 23;23(17):9512.發(fā)表了一篇題目為《外泌體微小RNA介導(dǎo)的腫瘤微環(huán)境中胰腺癌細(xì)胞與癌癥相關(guān)成纖維細(xì)胞之間的串?dāng)_》腫瘤靶向藥物治療基因檢測(cè)臨床研究文章。該研究由Xiangyu Chu, Yinmo Yang, Xiaodong Tian 等完成。促進(jìn)了腫瘤的正確治療與個(gè)性化用藥的發(fā)展，進(jìn)一步強(qiáng)調(diào)了基因信息檢測(cè)與分析的重要性。

腫瘤靶向藥物及正確治療臨床研究內(nèi)容關(guān)鍵詞：

數(shù)據(jù)中心,癌癥相關(guān)成纖維細(xì)胞,外泌體 miRNA,腫瘤微環(huán)境

腫瘤靶向治療基因檢測(cè)臨床應(yīng)用結(jié)果

胰腺導(dǎo)管腺癌（PDAC）是惡性程度賊高的消化道腫瘤之一，具有早期診斷率低、侵襲性強(qiáng)、轉(zhuǎn)移早等特點(diǎn)。 胰腺導(dǎo)管腺癌中豐富的基質(zhì)細(xì)胞、致密的細(xì)胞外基質(zhì)和血液供應(yīng)不足限制了化療藥物的滲透，導(dǎo)致目前的治療方案療效不佳。癌癥相關(guān)成纖維細(xì)胞 (CAF) 是腫瘤微環(huán)境中的主要基質(zhì)細(xì)胞。腫瘤細(xì)胞可以分泌外泌體促進(jìn)活化CAFs的產(chǎn)生，同時(shí)癌癥相關(guān)成纖維細(xì)胞分泌的外泌體有助于促進(jìn)腫瘤進(jìn)展。外泌體中miRNAs的異常表達(dá)參與了腫瘤細(xì)胞與癌癥相關(guān)成纖維細(xì)胞的相互作用，這為外泌體miRNAs在胰腺導(dǎo)管腺癌診斷和治療中的應(yīng)用提供了可能。本文綜述了腫瘤微環(huán)境中胰腺導(dǎo)管腺癌細(xì)胞與CAFs串?dāng)_中外泌體miRNA的作用機(jī)制，以期加深對(duì)TME調(diào)控的認(rèn)識(shí)，并為設(shè)計(jì)針對(duì)人胰腺導(dǎo)管腺癌中外泌體miRNA的診斷和治療靶點(diǎn)提供依據(jù)。關(guān)鍵詞：PDAC ;癌癥相關(guān)成纖維細(xì)胞；外泌體 miRNA；腫瘤微環(huán)境。

腫瘤發(fā)生與反復(fù)轉(zhuǎn)移國際數(shù)據(jù)庫描述：

Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant digestive tumors, characterized by a low rate of early diagnosis, strong invasiveness, and early metastasis. The abundant stromal cells, dense extracellular matrix, and lack of blood supply in PDAC limit the penetration of chemotherapeutic drugs, resulting in poor efficacy of the current treatment regimens. Cancer-associated fibroblasts (CAFs) are the major stromal cells in the tumor microenvironment. Tumor cells can secrete exosomes to promote the generation of activated CAFs, meanwhile exosomes secreted by CAFs help promote tumor progression. The aberrant expression of miRNAs in exosomes is involved in the interaction between tumor cells and CAFs, which provides the possibility for the application of exosomal miRNAs in the diagnosis and treatment of PDAC. The current article reviews the mechanism of exosomal miRNAs in the crosstalk between PDAC cells and CAFs in the tumor microenvironment, in order to improve the understanding of TME regulation and provide evidence for designing diagnostic and therapeutic targets against exosome miRNA in human PDAC.Keywords: PDAC; cancer-associated fibroblasts; exosomal miRNAs; tumor microenvironment.