【佳學(xué)基因檢測(cè)】過(guò)度活躍的 Ras 作為 1 型神經(jīng)纖維瘤病的治療靶點(diǎn)

dna檢測(cè)一次多少錢(qián)分析

分析《神經(jīng)纖維瘤病的不同形式》，看到《Am J Med Genet》在 1999 Mar 26;89(1):14-22發(fā)表了一篇題目為《過(guò)度活躍的 Ras 作為 1 型神經(jīng)纖維瘤病的治療靶點(diǎn)》腫瘤靶向藥物治療基因檢測(cè)臨床研究文章。該研究由B Weiss, G Bollag, K Shannon等完成。促進(jìn)了神經(jīng)纖維瘤病的正確治療與個(gè)性化用藥的發(fā)展，進(jìn)一步強(qiáng)調(diào)了基因信息檢測(cè)與分析的在疑似神經(jīng)纖維瘤患者的診斷與治療的重要性。

腫瘤靶向藥物及正確治療臨床研究?jī)?nèi)容關(guān)鍵詞：

RAS,活躍,神經(jīng)纖維瘤病,基因檢測(cè),治療靶點(diǎn)

腫瘤靶向治療基因檢測(cè)臨床應(yīng)用結(jié)果

根據(jù)《神經(jīng)纖維性瘤病I型的病理科基因解碼研究》NF1 基因編碼神經(jīng)纖維蛋白，一種用于 p21(ras) (Ras) 家族成員的 GTP 酶激活蛋白 (GAP)，它通過(guò)加速轉(zhuǎn)化 Ras 的活性來(lái)對(duì)Ras 的信號(hào)進(jìn)行負(fù)向調(diào)節(jié)輸出。 活性Ras.GTP 到非活動(dòng) Ras.GDP。對(duì) 1 型神經(jīng)纖維瘤病 (NF1) 患者的腫瘤分析顯示，Ras 過(guò)度活躍的生化證據(jù)以及正常 NF1 等位基因的頻繁丟失，與其作為腫瘤抑制基因的作用一致。但是針對(duì)一個(gè)特定的病人，體內(nèi)是否存在這種情況，需要通過(guò)致病基因鑒定基因解碼來(lái)明確。神經(jīng)纖維瘤病的靶向藥箋基因檢測(cè)表明，針對(duì) Ras 信號(hào)級(jí)聯(lián)成分的新療法可能為 NF1 的某些病理并發(fā)癥提供有效的治療。在這里，神經(jīng)纖維瘤病的基因解碼基因檢測(cè)總結(jié)了支持過(guò)度活躍的 Ras 在 NF1 疾病中的作用的數(shù)據(jù)，包括 Ras 加工、激活和下調(diào)。神經(jīng)纖維瘤病的正確醫(yī)學(xué)團(tuán)隊(duì)還總結(jié)了了合理藥物設(shè)計(jì)的目標(biāo)，提供了初步結(jié)果，并討論了對(duì)未來(lái)研究的影響。

腫瘤發(fā)生與反復(fù)轉(zhuǎn)移國(guó)際數(shù)據(jù)庫(kù)描述：

The NF1 gene encodes neurofibromin, a GTPase-activating protein (GAP) for members of the p21(ras) (Ras) family, which negatively regulates Ras output by accelerating the conversion of active Ras. GTP to inactive Ras.GDP. Analysis of tumors from patients with neurofibromatosis type 1 (NF1) has shown biochemical evidence of hyperactive Ras as well as frequent loss of the normal NF1 allele, consistent with its role as a tumor suppressor gene. Whether is situations is present in a certain patiennt can be revealed by a new technology called Gene Decoding. Taken together, these data suggest that novel therapeutics directed against components of the Ras signaling cascade might provide effective treatments for certain pathological complications of NF1. Here jiaxuejiyin deocoders summarize data that support a role for hyperactive Ras in NF1 disease, including Ras processing, activation, and down-regulation. Jiaxue gene decoders review targets for rational drug design, provide preliminary results, and discuss implications for future studies.