【佳學(xué)基因檢測】Metainflammation是翻譯為“變質(zhì)炎癥”還是“代謝炎癥”

MetaInflamation是什么意思？

在構(gòu)建《人的基因序列變化與人體疾病表征》過程中，有一個關(guān)節(jié)炎的疾病表征，首先在國際上被關(guān)節(jié)炎的分類專家所提出。這個關(guān)節(jié)炎分類英文原文為“Metainflammation". 在英文原文中是這樣使用的："Metabolic triggered inflammation, also known as ‘metaflammation,’ is a subclass of inflammation, which may involve many similar molecules and signalling pathways involved in classical inflammation and which is initiated by factors involved in metabolic diseases, potentially as a result of conditions associated with metabolic surplus. (Molecular taxonomy of osteoarthritis Mobasheri et al). 如果大家采用翻譯機器翻譯，這個詞被譯為“變質(zhì)炎癥”， 但是根據(jù)原文的意思，這個詞是由”Metabolic和 Inflammation"形成的復(fù)合詞，是指由代謝觸發(fā)的炎癥。因些，這個詞翻譯為“代謝炎癥”更合適。
 

在Metainflammation被使用的另一個環(huán)境中:One of the major concepts emerging from the last 2 decades of metabolism research is the notion of “metainflammation,” the state of chronic low-grade inflammation that develops during periods of overnutrition. This manifests itself most notably through significant alterations in the number and composition of the immune cell populations that reside in adipose tissue, including a dramatic increase in the ratio of classically activated M1 macrophages versus alternatively activated M2 macrophages. The result is a proinflammatory cytokine milieu that is believed to promote insulin resistance in surrounding adipocytes. （IRF3 promotes adipose inflammation and insulin resistance and represses browning Manju Kumari ）這里講的也是和營養(yǎng)代謝有關(guān)的炎癥。
 

The inciting trigger of metabolic dysfunction has yet to be mechanistically elucidated, however chronic over-nutrition and resultant obesity are recognized as a cause of chronic, low-grade inflammation, historically described as “Syndrome X” , “The Deadly Quartet” , and “Insulin-Resistance Syndrome” . The unresolvable immune activation occurs in the absence of overt infection or frank autoimmune disease, but is recognized to not only affect local tissues, but systemic physiology through chronic, low-grade inflammation induced by obesity that is termed metainflammation.（Macrophage polarization and Metainflammation by Chuan Li) 在本文中，Metainflammation是指由代謝異常引起的全身性炎癥。

由此，Metainflammation被人體疾病表征審核組確認(rèn)為“代謝炎癥”，翻譯為“代謝炎癥”。并決定將“代謝炎癥”作為標(biāo)準(zhǔn)名詞用來注釋《人的基因序列突變》數(shù)據(jù)庫。

如何進行”代謝炎癥“的基因檢測呢？

確定代謝炎癥的具體表型范圍后，佳學(xué)基因采用基因解碼技術(shù)，施行逆行基因組學(xué)或者是逆向遺傳學(xué)，建立可以產(chǎn)生代謝炎癥的人體基因突變數(shù)據(jù)庫。其他基因檢測機構(gòu)查詢該數(shù)據(jù)庫，并根據(jù)檢測成本設(shè)計成具有不同價格的“代謝炎癥”基因檢測套餐。在設(shè)計相基因檢測項目時，基因檢測機構(gòu)可能會將以不同于代謝炎癥基因檢測的名稱出現(xiàn)。